Genes, Free Full-Text
Por um escritor misterioso
Descrição
KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation. KMT2A has a crucial role in gene expression, thus it is associated to pathological conditions when found mutated. KMT2A germinal mutations are associated to Wiedemann–Steiner syndrome and also in patients with initial clinical diagnosis of several other chromatinopathies (i.e., Coffin–Siris syndromes, Kabuki syndrome, Cornelia De Lange syndrome, Rubinstein–Taybi syndrome), sharing an overlapping phenotype. On the other hand, KMT2A somatic mutations have been reported in several tumors, mainly blood malignancies. Due to its evolutionary conservation, the role of KMT2A in embryonic development, hematopoiesis and neurodevelopment has been explored in different animal models, and in recent decades, epigenetic treatments for disorders linked to KMT2A dysfunction have been extensively investigated. To note, pharmaceutical compounds acting on tumors characterized by KMT2A mutations have been formulated, and even nutritional interventions for chromatinopathies have become the object of study due to the role of microbiota in epigenetic regulation.
Genetic Genie: Free Raw DNA Data Analysis and MTHFR
The complete sequence of a human genome
Genetic Genie – Free Raw DNA Data Analysis Upload Tools
IJMS, Free Full-Text
Gene, Definition, Structure, Expression, & Facts
Multi-context genetic modeling of transcriptional regulation
Mythic Zip 5,67 Mb Ml Herunterladen - Colaboratory
Genes, Free Full-Text
Stream *DOWNLOAD$$ ⚡ Deep Nutrition: Why Your Genes Need
Multiyear Factor VIII Expression after AAV Gene Transfer for
Frontiers Insights Into Genetic and Molecular Elements for
Genes, Chromosomes and Cancer - Wiley Online Library
Race and Genetic Ancestry in Medicine — A Time for Reckoning with
de
por adulto (o preço varia de acordo com o tamanho do grupo)