GPC2-CAR T cells tuned for low antigen density mediate potent
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Descrição
Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect
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GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma
CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. - Abstract - Europe PMC
Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect
Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours. - Abstract - Europe PMC
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CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research
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Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors
Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges
Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours
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