Vaccines, Free Full-Text

Por um escritor misterioso

Descrição

The ideal vaccine against viral infections should elicit antibody responses that protect against divergent strains. Designing broadly protective vaccines against SARS-CoV-2 and other divergent viruses requires insight into the specific targets of cross-protective antibodies on the viral surface protein(s). However, unlike therapeutic monoclonal antibodies, the B-cell epitopes of vaccine-induced polyclonal antibody responses remain poorly defined. Here we show that, through the combination of neutralizing antibody functional responses with B-cell epitope mapping, it is possible to identify unique antibody targets associated with neutralization breadth. The polyclonal antibody profiles of SARS-CoV-2 index-strain-vaccinated rabbits that demonstrated a low, intermediate, or high neutralization efficiency of different SARS-CoV-2 variants of concern (VOCs) were distinctly different. Animals with an intermediate and high cross-neutralization of VOCs targeted fewer antigenic sites on the spike protein and targeted one particular epitope, subdomain 1 (SD1), situated outside the receptor binding domain (RBD). Our results indicate that a targeted functional antibody response and an additional focus on non-RBD epitopes could be effective for broad protection against different SARS-CoV-2 variants. We anticipate that the approach taken in this study can be applied to other viral vaccines for identifying future epitopes that confer cross-neutralizing antibody responses, and that our findings will inform a rational vaccine design for SARS-CoV-2.
Vaccines, Free Full-Text
COVID-19 Vaccination Clinical and Professional Resources
Vaccines, Free Full-Text
Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient
Vaccines, Free Full-Text
Revisiting COVID-19 vaccine hesitancy around the world using data
Vaccines, Free Full-Text
Influenza and COVID-19 Vaccination Coverage Among Health Care
Vaccines, Free Full-Text
Opposition to voluntary and mandated COVID-19 vaccination as a
Vaccines, Free Full-Text
The world will soon have covid-19 vaccines. Will people have the jabs?
Vaccines, Free Full-Text
FREE Vaccine Clinic - Santa Rita School
Vaccines, Free Full-Text
Free Flu & COVID-19 Vaccine Clinic - Franklin
Vaccines, Free Full-Text
Clinical Resources Archive
Vaccines, Free Full-Text
Vaccines, Free Full-Text
Vaccines, Free Full-Text
World leaders unite in call for a people's vaccine against COVID
Vaccines, Free Full-Text
COVID-19 Vaccine Access for Uninsured Adults this Fall
Vaccines, Free Full-Text
Free Covid-19 Vaccines in Tucson.
de por adulto (o preço varia de acordo com o tamanho do grupo)