Casa
bronstein meier ii

An Historical Review of Steps and Missteps in the Discovery of

Por um escritor misterioso

Descrição
The epidemic of obesity cries out for strategies to prevent it, and for treatment when prevention fails. Yet despite the obvious need, the path to developing anti-obesity medications is strewn with failures. This review examines some historical developments in the management of obesity prior to the 20th century followed by more recent efforts to find a “cure.” Since obesity has been a human disease since paleolithic times, discussion of treatment prior to the scientific revolution in about 1500 CE will include comments on treatment of obesity in Grecian Medicine and the Treatment of Sancho “The Fat” King of Leon in 10th century northern Spain. We will then trace treatment trends through time, ending in the early 21st century. In the first half of the 20th century there were 3 main themes associated with drug treatment of obesity: use of thyroid hormones, the interlude with dinitrophenol as drug regulation was beginning to expand, and the introduction of amphetamines and Rainbow Pills. In the second half of the 20th century many new treatment approaches were explored as the scientific basis for understanding regulation of food intake expanded, particularly after the discovery of leptin in 1994. The fact that amphetamine could be addictive led to the search for compounds that acted in the central nervous system with retained the anorectic properties but were not addictive. Both anti-depressant and anticonvulsive drugs were evaluated with disappointing results. The idea of enhancing energy expenditure with thermogenic drugs was pursued but led to a dead end. Peptides, metabolic drugs and drugs that act on the gastrointestinal track are currently under exploration. This chapter makes an effort to answer the question of why it has been so difficult to develop effective medications for the management of obesity. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text, WWW.ENDOTEXT.ORG.
An Historical Review of Steps and Missteps in the Discovery of
How to write the background of your study
An Historical Review of Steps and Missteps in the Discovery of
Fauci candidly reflects on missteps, successes of the US Covid-19
An Historical Review of Steps and Missteps in the Discovery of
Scientific method - Wikipedia
An Historical Review of Steps and Missteps in the Discovery of
The Royal Archives Reveals the Hidden Genius Behind George III's
An Historical Review of Steps and Missteps in the Discovery of
Book Review: Former Aide Pens Racy, Defensive Bio of S.C.
An Historical Review of Steps and Missteps in the Discovery of
Hard-Headed Man Science History Institute
An Historical Review of Steps and Missteps in the Discovery of
7 Things to Avoid When Buying a Used Car
An Historical Review of Steps and Missteps in the Discovery of
The Marvels—And Mistakes—Of Supertall Skyscrapers - The Atlantic
An Historical Review of Steps and Missteps in the Discovery of
Historical Method: 5 step process historians use to write history
An Historical Review of Steps and Missteps in the Discovery of
16 Blogging Mistakes to Avoid in 2023, According to HubSpot Bloggers
An Historical Review of Steps and Missteps in the Discovery of
How To Avoid Mistakes When Enrolling in Medicare
An Historical Review of Steps and Missteps in the Discovery of
The Biggest Mistakes Companies Make With Cybersecurity—and How to
An Historical Review of Steps and Missteps in the Discovery of
ERP Implementation: The 9-Step Guide – Forbes Advisor
An Historical Review of Steps and Missteps in the Discovery of
How to Plan a Marketing Budget in 6 Steps: 2024 Guide
An Historical Review of Steps and Missteps in the Discovery of
Guttenberg plagiarism scandal - Wikipedia
de por adulto (o preço varia de acordo com o tamanho do grupo)